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Endocrine Abstracts

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ea0035oc2.3 | Adrenal clinical | ECE2014

Prognostic value of DNA methylation in adrenocortical carcinomas: an ENSAT study

Assie Guillaume , Jouinot Anne , Libe Rossella , Barreau Olivia , Papathomas Thomas , Hamzaoui Nadim , Sbiera Silviu , Ronchi Christina , Kroiss Matthias , Waldmann Jens , Quinkler Marcus , Beuschlein Felix , Mannelli Massimo , Luconi Michaela , Mantero Franco , Groussin Lionel , Baudin Eric , de Krijger Ronald , Fassnacht Martin , Bertherat Jerome

Background: The prognosis of adrenocortical carcinomas (ACCs) is heterogeneous. Genome-wide methylation analysis of tumor DNA identified a sub-group of ACCs from the French COMETE network with CpG island hypermethylation evoking a CpG island methylator phenotype (CIMP). These ACCs are associated with a poorer prognosis (Barreau, JCEM 2013).The aim was to validate the prognostic value of CIMP in a large multicentric independent cohort from ENSAT (European...
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ea0056oc11.2 | Clinical practice in endocrine tumours: combining conventional and molecular features | ECE2018

Molecular classifiers refine the prognostic stratification of adrenocortical carcinoma

Jouinot Anne , Assie Guillaume , Fassnacht Martin , Libe Rossella , Garinet Simon , Jacob Louis , Faillot Simon , Hamzaoui Nadim , Neou Mario , Sakat Julien , Perlemoine Karine , Sibony Mathilde , Tissier Frederique , Dousset Bertrand , Sbiera Silviu , Ronchi Cristina , Kroiss Matthias , Korpershoek Esther , De Krijger Ronald , Waldmann Jens , Quinkler Marcus , Tabarin Antoine , Chabre Olivier , Coste Joel , Luconi Michaela , Mannelli Massimo , Groussin Lionel , Bertagna Xavier , Baudin Eric , Amar Laurence , Beuschlein Felix , Bertherat Jerome

Background: Adrenocortical cancer (ACC) is an aggressive tumour with heterogeneous prognosis. Pan-genomic studies identified molecular subgroups of ACC, remarkably associated with outcome. For routine prospective use, targeted molecular measures are needed, combined into reasonably easy and cheap techniques. The aim was to develop and validate different combinations of targeted molecular markers reflecting the molecular subgroup, and compare their prognostic value to standard ...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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